Controlled Activity Polymers: Acrylic Acid Copolymers of b-Naphthyl Acrylate, 2-Acrylamido(b-Naphthyl)Valerate, 3-Acrylamido-3-Methyl (b-Naphthyl)Butanoate, and 6-Acrylamido(b-Naphthyl)-Caproate: Release Behavior

摘要

Controlled hydrolytic release studies of polymers with pendant bioactive groupshave been widely studied for applications such as drug delivery and controlled herbicide release systems. Release studies of pendent bioactive compounds have been shown to be dependent upon the nature of the labile bond and/or its distance from the polymer backbone. Other parameters such as particle size, molecular weight, molecular weight distribution, chemical structure and hydrophilicity have also been shown to influence rates of hydrolysis. In a preceding paper of this series we detailed the synthesis and structural characterization of acrylic acid (AA) copolymers with naphthol esters of varying pendant structures. In our continuing efforts to model copolymers for use as controlled release systems, we now report the release properties of these copolymers as related to length and structure of the spacer group and copolymer microstructure. jg p.3.