PROCESS FOR PREPARING NON-PASSAGEABLE VIRUSES AND METHOD FOR MAINTAINING REPLICATING AND EXPRESSING AT LEAST A PORTION OF THE GENOME OF AN NP-VIRUS COMPRISING

摘要

DNA transfer vector comprising the genome of a non-passageable virus. The vector can be a plasmid and the virus hepatitis B virus. The production of antigenic protein by the expression of the recombinant DNA in a host cell. The enhancing of the antigenicity and the stability of the antigenic protein by chemical modification.