PROCESS FOR THE PREPARATION OF CONJUGATES IN WHICH A MONOVALENT CARBOXYLIC IONOPHORE IS ASSOCIATED BY MEANS OF A COVALENT BOND WITH A MACROMOLECULE, WHICH ARE USEFUL AS IMMUNOTOXIN POTENTIATORS

摘要

IN THE CANADIAN PATENT & TRADEMARK OFFICEPATENT APPLICATIONentitled: Process for the preparation of conjugatesin which a monovalent carboxylic ionophore is associatedby means of a covalent bond with a macromolecule, whichare useful as immunotoxin potentiators.in the names of: Franz K. JANSENPierre GROSAssignee: Société anonyme styled: SANOFIABSTRACT OF THE DISCLOSUREThe present invention relates to the preparationof conjugates in which a monovalent carboxylic ionophoreis associated by means of a covalent bond with amacromolecule chosen from antibodies, fragments ofantibodies, proteins such as peptide hormones or humanproteins, and peptide ligands.These conjugates are suitable as immunotoxinpotentiators.