CONJUGATES IN WHICH A MONOVALENT CARBOXYLIC IONOPHORE IS ASSOCIATED BY MEANS OF A COVALENT BOND WITH A MACROMOLECULE,THEIR USE AS IMMUNOTOXIN POTENTIATORS AND THE INTERMEDIATE ACTIVATED IONOPHORES

摘要

The present invention relates to conjugates combining, via covalent bonding, a monovalent carboxylic ionophore and a macromolecule chosen from antibodies, fragments of antibodies, proteins, such as peptide hormones or human proteins and peptide ligands. These conjugates are suitable as potentiating agents for immunotoxins.