16-METHYL SUBSTITUTED STEROIDS DERIVED FROM PREGNA 1,4-DIENE3,20-DIONE, THEIR PREPARATION AND APPLICATION TO THE PREPARATION OF 16-METHYLENE STEROIDS AND NOVEL INTERMEDIATE COMPOUNDS

摘要

The invention relates to compounds (I): (I) where R is methyl or -CH2OH free or protected, R1 and R'1 are methyl: branched alkyl (5 to 8 carbon atoms), aryl (up to 10 carbon atoms), heteroaryl or benzyl, n and m are O or 1, R2 and R3 are hydrogen or R2 is fluorine and R3 is formyloxy or acetyloxy and the dotted lines symbolize a possible bond, their preparation from a compound delta-16 (17), their application to the preparation of 16-methylene derivatives and new intermediates.