NOVEL BI-AROMATIC COMPOUNDS DERIVED FROM A SALICYLIC PATTERN, METHOD OF PREPARATION AND USE IN HUMAN AND VETERINARY MEDICINE AND IN COSMETICS

摘要

Bi-aromatic compounds caractérisé fait que They comply-with general formula (I) where: R1 is -CH3, -CH2OH, -COR8, gold -CH2OCOR9, R8 is H, OH, -OR10, -N (rr), gold alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r 'being H, alkyl, aryl aralkyl, etc., r and r' together forming a heterocycle, R9 is alkyl, alkenyl or a sugar residue, R2 and R3 are - OR11 -OCOR11 gold, R11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R3 aussi Being H, R4 is H, OH, alkyl, alkoxy, F, Cl, CF3, R5 and R7 are H, OH, alkoxy, Substituted or alkyl .alpha .-. alpha .'- DISUBSTITUTED etc alkyl, R6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R5 and R7 can not be OH Simultaneously gold alkoxy and R4, R5, R6 and R7 can not be H Simultaneously , R5 and R6 or R6 and R7 May form a ring of 5 or 6 links with the aromatic ring. X is selected from (i) -C (R13R14-C (R16R18-W -, (ii) -CR14R16-WC (R18R19) - (iii) -C (R13R14) -C (R15R16-C (R18R20) -, ( iv) -CR17 = CR21-C (R13R14) - Where W is 0, -NR12 or -S (O) n, n = 0, 1 or 2, R13, R15 and R20 are H, -OR11, -OCOR11, etc. R14, R16, R18 and R19 are H, aralkyl, alkyl, etc. When X is (i) R13 and R14 May form = N-OR11 or = N-OCOR11, When X is (iii) or (iv) R14 , R16 and R18 are OR11 aussi -OCOR11 gold, gold R13, R14 or R15, R16 May together form = NOR11 or = N-OCOR11, R12 is H, alkyl, aralkyl, alkenyl, alkynyl or fluoroalkyl, R17 is H, hydroxyl, . gold alkyl alkoxy, R21 is H or alkyl and the salts of the compounds of formula (I) compound biaromatic, characterized in that they correspond to the general formula (I) wherein: R1 is -CH3, - CH2OH, -COR8, or -CH2OCOR9, R8 is H, OH, -OR10, -N (rR), or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r 'being H, alkyl, aryl, aralkyl , etc., r and r 'together wheat heterocycle, R9 is alkyl, alkénile or a radical of alkyl, alkoxy, F, Cl, -CF2, R5 and R7 are H, OH, alkoxy, alkyl or substituted alkyl .alpha.- .alpha .'- disubstituted, etc., R6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R5 and R7 are not simultaneously be OH or alkoxy and R4, R5, R6 and R7 can not be H simultaneously, R5 and R6 or R6 and R7 may form with the aromatic ring a 5- or 6-membered ring, X is selected from: (i) -C (R13R14) -C (R16R18) -W- (ii) -C (R14R16) -WC (R18R19) -, (iii) -C (R13R14) -C (R15R16) -C (R18R20) -, (iv) etc., R14, R16, R18 and R19 are H, aralkyl, alkyl, etc., when X is ( i) R13 and R14 may form = N-OR11 or = N-OCOR11, when X is (iii) or (iv) R14, R16 and R18 are also -OR11 or -OCOR11, or R13, R14 or R15, R16 , taken together may form = NOR11 or = N-OCOR11, R12 is H, alkyl, aralkyl, alkenyl, alkynyl or fluoroalkyl, R 17 is H, hydroxyl, alkyl or alkoxy, R21 is H or alkyl, and the salts of the compounds of formula (I).