NOVEL BI-AROMATIC COMPOUNDS DERIVED FROM A SALICYLIC PATTERN, METHOD OF PREPARATION AND USE IN HUMAN AND VETERINARY MEDICINE AND IN COSMETICS

摘要

Bi-aromatic compounds characterized in that they comply with general formula (I), where: R1 is -CH3, -CH2OH, -COR8, or -CH2OCOR9, R8 is H, OH, -OR10, -N (rr '), or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r 'being H, alkyl, aryl aralkyl, etc, r and r' together forming a heterocycle, R9 is alkyl, alkenyl or a sugar residue, R2 and R3 are - OR11 or -OCOR11, R11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R3 also being H, R4 is H, OH, alkyl, alkoxy, F, CI, -CF3, R5 and R7 are H, OH, alkoxy, substituted alkyl or .alpha .-. alpha .'- disubstituted alkyl etc, R6 is H, OH, alkyl, alkoxy, cycloalkyl, etc, R5 and R7 cannot simultaneously be OH or alkoxy and R4, R5, R6 and R7 cannot simultaneously be H , R5 and R6 or R6 and R7 may form a ring of 5 or 6 links with the aromatic ring. X is selected from (i) -C (R13R14-C (R16R18 -W-, (ii) -CR14R16-WC (R18R19) - (iii) -C (R13R14) -C (R15R16-C (R18R20) -, ( iv) -CR17 = CR21-C (R13R14) - where W is 0, -NR 12 or S (O) n, n = 0, 1 or 2, R13, R15 and R20 are H, -OR11, -OCOR11, etc , R14, R16, R18 and R19 are H, aralkyl, alkyl, etc, when X is (i), R13 and R14 may form = N-OR11 or = N-OCOR11, when X is (iii) or (iv), R14, R16 and R18 are also - OR11 or -OCOR11, or R13, R14 or R15, R16 together may form = NOR11 or = N-OCOR11, R12 is H, alkyl, aralkyl, alkenyl, alkynyl or fluoroalkyl, R17is H, hydroxyl , alkyl or alkoxy, R21 is H or alkyl and the salts of the compounds of formula (I). Bi-aromatic compound, characterized by the fact that they correspond to the general form (I) in which: R1 is -CH3 , -CH2OH, -COR8, or -CH2OCOR9, R8 is H, OH, -OR10, -N (rr '), or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl , aralkyl, etc., r and r 'together form a heterocycle, R9 is alkyl, alkenile or r est of alkyl, alkoxy, F, Cl, -CF2, R5 and R7 are H, OH, alkoxy, substituted alkyl or alkyl .alpha .-. alpha .'- unsubstituted, etc, R6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R5 and R7 cannot simultaneously be OH or alkox y and R4, R5, R6 and R7 cannot be simultaneously H, R5 and R6 or R6 and R7 can form with the aromatic ring a 5 or 6-membered ring, X is chosen from: (i) -C (R13R14) -C (R16R18) -W-, (ii) -C (R14R16) -WC (R18R19) -, (iii) -C (R13R14) - C (R15R16) -C (R18R20) -, (iv) etc, R14, R16, R18 and R19 are H, aralkyl, alkyl, etc, when X is (i), R13 and R14 can form = N-OR11 or = N-OCOR11, when X is (iii) or (iv), R14, R16 and R18 are also -OR11 or -OCOR11, or R13, R14 or R15, R16, taken together can form = NOR11 or = N-OCOR11, R12 is H, alkyl , aralkyl, alkenyl, alkynyl or fluoroalkyl, R17 is H, hydroxyl, alkyl or alkoxy, R21 is H or alkyl, and the salts of the compounds of formula (I).