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BIOLOGICALLY ACTIVE AMPHIPHILIC PEPTIDES AND METHOD OF INHIBITING GROWTH OF TARGET CELLS, VIRUS OR VIRALLY-INFECTED CELL
BIOLOGICALLY ACTIVE AMPHIPHILIC PEPTIDES AND METHOD OF INHIBITING GROWTH OF TARGET CELLS, VIRUS OR VIRALLY-INFECTED CELL
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机译:具有生物活性的两亲肽和抑制靶细胞,病毒或病毒感染细胞生长的方法
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摘要
A biologically active amphiphilic peptide which in accordance with an aspect of the present invention, includes one of the following basic structures X1 through X7, wherein: X1 is -[R1-R2-R2-R3-R1-R2-R2]-n; X2 is -[R2-R2-R3-R1-R2-R2-R1]-n; X3 is -[R2-R3-R1-R2-R2-R1-R2]-n; X4 is -[R3-R1-R2-R2-R1-R2-R2]-n; X5 is-[R1-R2-R2-R1-R2-R2-R3]-n; X6 is -[R2-R2-R1-R2-R2-R3-R1]-n; and X7 is-[R2-R1-R2-R2-R3-R1-R2]-n; wherein R1 is a basic hydrophilic amino acid, R2 is a hydrophobic amino acid, R3 is a neutral hydrophilic, basic hydrophilic or hydrophobic amino acid and n is from 2 to 5. The peptide compositions are used to inhibit growth of a target cell, virus or virally-infected cell.
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