DNA CAPABLE OF SITE-SPECIFIC INTEGRATION INTO MYCOBACTERIA

摘要

Type of DNA which makes it possible to integrate DNA into a part of mycobacterium chromosome, comprising a first DNA sequence which is a part of phage DNA coding for bacteriophage integration into a mycobacterium chromosome, and a second sequence DNA encoding a heterologous protein or polypeptide for the mycobacterium into which the DNA is to be integrated. DNA of this type can be integrated into mycobacteria, which can then be administered as a vaccine and / or as a therapeutic agent.