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METHOD OF SYNTHESIS OF OPTICALLY ACTIVE BROMO-SUBSTITUTED 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE
METHOD OF SYNTHESIS OF OPTICALLY ACTIVE BROMO-SUBSTITUTED 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE
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机译:光学活性的溴取代的2-氨基-1,2,3,4-四氢萘的合成方法
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摘要
The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which exhibit binding activity at the serotonin 1A receptor and 3-aminochromane intermediates. The pharmaceutical compounds have the formula CHEM in which R is C1-C4 alkyl, allyl, or cyclopropylmethyl; R1 is hydrogen, C1-C4 alkyl, allyl, cyclopropylmethyl, or aryl(C1-C4-alkyl); R2 is hydrogen or methyl; X is -CH2- or -O-; R3 is C1-C8 alkyl, aryl, substituted aryl, aryl(C1-C4-alkyl), substituted aryl(C1-C4 alkyl), or C5-C7 cycloalkyl; n is 0, 1, or 2; and pharmaceutically acceptable acid addition salts thereof.
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机译:本发明提供了新颖的环取代的2-氨基-1,2,3,4-四氢萘,它们对5-羟色胺1A受体和3-氨基苯并烷中间体具有结合活性。所述药物化合物具有式,其中R为C1-C4烷基,烯丙基或环丙基甲基; R1是氢,C1-C4烷基,烯丙基,环丙基甲基或芳基(C1-C4-烷基); R 2是氢或甲基; X是-CH 2-或-O-; R3为C1-C8烷基,芳基,取代的芳基,芳基(C1-C4-烷基),取代的芳基(C1-C4烷基)或C5-C7环烷基; n为0、1或2;及其药学上可接受的酸加成盐。
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