METHOD OF SYNTHESIS OF OPTICALLY ACTIVE BROMO-SUBSTITUTED 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE

摘要

use: intermediate products u0434u043bu00a0 synthesis of compounds that have a zero sum activity in the 5 HTiA and u0438u0441u043fu043eu043bu044cu0437u0443u044eu0442u0441u00a0 medicine u0434u043bu00a0 u043bu0435u0447u0435u043du0438u00a0 sexual dysfunction, anxiety, depression and so on.the essence of the u0438u0437u043eu0431u0440u0435u0442u0435u043du0438u00a0: product is optically active u0431u0440u043eu043cu0437u0430u043cu0435u0449u0435u043du043du044bu0439 2 - amino - 1,2,3,4 - u0442u0435u0442u0440u0430u0433u0438u0434u0440u043eu043du0430u0444u0442u0430u043bu0438u043d s - lu, u0432u0433 n invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 to mode u043fu043eu043bu0443u0447u0435u043du0438u00a0 new u0441u043eu0435u0434 u0438u043du0435u043du0438u0439 general formula i bf n i - n, - Ri Ri or f n u04331 n rt 4r 2 where Ri - c1 - c4 - u0430u00a0u043au0438u043b and r2 is h, or c1 - c4 - u0430u043bu043au0438u043b reagent 1: 8 - bromine - 2 - u0442u0435u0442u0440u0430u043bu043eu043d.agent 2: optically active n - u043du0438u0442u0440u043eu0444u0435u043du0435u0442u0438u043bu0430u043cu0438u043d reagent 3: 2 - {a} - p - methyl - u043du0438u0442u0440u043eu0431u0435u043du0437u0438u043b u0430u043cu0438u043du043eu0442u0435u0442u0440u0430 min. reagent 4: u0430u043bu043au0430u043du043eu0438u043bu0445u043bu043eu0440u0438u0434. u0443u0441u043bu043eu0432u0438u00a0 process: the separation of optical isomers. reagent 5: n - 1 - (4 - u043du0438u0442u0440u043eu0444u0435u043du0438u043b) - ethyl n -