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Urea fusion process for the synthesis of 3-phenoxy-1- azetidinecarboxamides
Urea fusion process for the synthesis of 3-phenoxy-1- azetidinecarboxamides
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机译:尿素熔融法合成3-苯氧基-1-氮杂环丁烷甲酰胺
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摘要
This invention relates to an improved process for the preparation of 3- phenoxy-1-azetidinecarboxamides of Formula I which are useful ##STR1## in the treatment of epileptic seizures. Under Formula I, n is 1 to 3, X is H, halogen, trifluoromethyl, C.sub.1 -C.sub.4 alkyl, C. sub.1 -C.sub.4 alkoxy, acetyl, or aminocarbonyl, and R is H or methyl. This process involves heating a 3-phenoxyazetidine with urea to obtain the Formula I compound. Urea is inexpensive and easily removed by washing the solid Formula I product with water.
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