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UREA FUSION PROCESS FOR SYNTHESIS OF 3-PHENOXY- 1-AZETIDINECARBOXYAMIDE
UREA FUSION PROCESS FOR SYNTHESIS OF 3-PHENOXY- 1-AZETIDINECARBOXYAMIDE
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机译:尿素融合法合成3-苯氧基-1-氮杂环丁烷羧酰胺
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摘要
This invention relates to an improved process for the preparation of 3-phenoxy-1-azetidinecarboxamides of Formula I which are useful CHEM in the treatment of epileptic seizures. Under Formula I, n is 1 to 3, X is H, halogen, trifluoromethyl, C1-C4 alkyl, C1-C4 alkoxy, acetyl, or aminocarbonyl, and R is H or methyl. This process involves heating a 3-phenoxyazetidine with urea to obtain the Formula I compound. Urea is inexpensive and easily removed by washing the solid Formula I product with water.
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