Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis

摘要

A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are independently hydrogen, C.sub.1-6 alkyl, C.sub.1- 6 cycloalkyl, C.sub.1-3 alkoxy, n-butoxy, i-butoxy, sec-butoxy, R.sup.7 R. sup.8 N-- (wherein R.sup.7 and R.sup.8 are independently hydrogen or C. sub.1-3 alkyl), trifluoromethyl, trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl, phenoxy, benzyloxy, hydroxy, trimethylsilyloxy, diphenyl-t-butylsilyloxy, hydroxymethyl or -- O(CH.sub. 2).sub.l OR.sup.19 (wherein R.sup.19 is hydrogen or C.sub.1-3 alkyl, and l is 1,2 or 3); or when located at the ortho position to each other, R. sup.1 and R.sup.2, or R.sup.3 and R.sup.4 together form -- CH═CH--CH. dbd.CH--; or when located at the ortho position to each other, R.sup.1 and R.sup.2 together form --OC(R.sup.15 l) (R.sup.16)O-- (wherein R.sup. 15 and R.sup.16 are independently hydrogen or C.sub.1-3 alkyl); Y is --CH. sub.2 --, --CH.sub.2 CH.sub.2 --, --CH═CH--, --CH. sub.2 --CH═CH-- or -- CH═CH--CH.sub.2 --; and Z is --Q--CH.sub. 2 WCH.sub.2 --CO.sub.2 R.sup.12, ##STR2## (wherein Q is --C(O)--, --C(OR. sup.13).sub.2 -- or -- CH(OH)--; W is --C(O)--, --C(OR.sup.13).sub.2 -- or --C(R.sup.11) (OH)--; R.sup.11 is hydrogen atom or C.sub.1-3 alkyl; R. sup.12 is hydrogen or R. sup.14 (wherein R.sup.14 is physiologically hydrolyzable alkyl or M (wherein M is NH.sub.4, sodium, potassium, 1/2 calcium or a hydrate of lower alkyl amine, di-lower alkyl amine or tri- lower alkyl amine)); two R. sup.13 are independently primary or secondary C.sub.1-6 alkyl; or two R. sup.13 together form --(CH.sub.2).sub.2 -- or - -(CH.sub.2).sub.3 ; R.sup. 17 and R.sup.18 are independently hydrogen or C.sub.1-3 alkyl; and R.sup. 5 is hydrogen, C.sub.1-6 alkyl, C.sub.2-3 alkenyl, C.sub.3-6 cycloalkyl, ##STR3## wherein R.sup.9 is a hydrogen atom, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, bromo or trifluoromethyl), phenyl--(CH.sub.2).sub. m -- (wherein m is 1,2 or 3), -- (CH.sub.2).sub.n CH(CH.sub.3)--phenyl or phenyl--(CH.sub.2).sub.n CH(CH. sub.3)-- (wherein n is 0,1 or 2).