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Methods for identifying the DQw3.2 allele associated with increased risk of insulin-dependent diabetes mellitus
Methods for identifying the DQw3.2 allele associated with increased risk of insulin-dependent diabetes mellitus
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机译:鉴定与胰岛素依赖型糖尿病风险增加相关的DQw3.2等位基因的方法
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摘要
Methods for identifying individuals at increased risk of diabetes are disclosed. The methods disclosed utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a sinle gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2 allele. This method involves estimating the size of the hybridizable DNA fragment generated by a specific restriction endonuclease and therefrom determining the presence of the allele. A second preferred method involves the serologic detection of the DQw3.2 allele. Within this method, immunocomplexes formed between two different MAb's and separate portions of a cell collection are detected and the presence or absence of the allele determined.
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