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The solid abiotic base substance for bio mechanical microstructure body formation cell configuration method null to the microstructure body and the microstructure body which use
The solid abiotic base substance for bio mechanical microstructure body formation cell configuration method null to the microstructure body and the microstructure body which use
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机译:用于生物机械微结构体形成细胞构造方法的固体非生物基础物质,对使用的微结构体和微结构体无效
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摘要
The present invention relates to the location of biological cells 5 in a predetermined spatial disposition relative to each other on a solid non-biological substrate. According to the invention an extended generally planar surface of the substrate is provided with a plurality of surface discontinuities 4 at least partly defining cell adhesion enhanced and/or cell-adhesion orienting zones having a width of from 0.2 to 20 micrometers in a predetermined relation to each other and substantially spaced apart from each other. When a plurality of the cells 5 in a physiologically acceptable medium is brought into contact with said substrate surface cells attached to the substrate surface preferentially and/or in preferential orientations at said discontinuities 4.
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