MOLLUSCAN NEUROPEPTIDE HAVING FR STRUCTURE AT N-TERMINAL

摘要

PURPOSE: To obtain a new neuropeptide capable of providing a new means for pharmacological research. ;CONSTITUTION: The objective new neuropeptide is expressed by the following amino acid sequence formulas (a) and (b): (a) H-Phe-Arg-Thr-Phe-X-Y-OH and (b) H-Phe-Arg-Pro-Leu-OH (amino acid residue is noted by the three letter notation defined by the IUPAC and IUB; X denotes single bond, Glu residue or Gln residue; Y denotes single bond or Lys residue). Although this neuropeptide is a neuropeptide capable of suppressing strong contraction of an anterior byssus retractor muscle in Mytilus edulis by electrical stimulation and is obtained from a ganglion of Helix pomatia produced in Hungary by combining high- performance liquid chromatography, it can be synthesized by a commercially available automatic peptide synthesizer. This neuropeptide is not only useful as the neuropeptide but also capable of providing a new approach to medicines and agricultural chemicals, etc.;COPYRIGHT: (C)1994,JPO&Japio