MOLLUSCAN NEUROPEPTIDE HAVING STRUCTURE OF SSXI IN C-TERMINAL

摘要

PURPOSE: To obtain a new means for pharmacological research using a new neuropeptide. ;CONSTITUTION: The objective new neuropeptide represented by the following amino acid sequence formulas (a) and (b): (a) H-Pro-Ile-Asp-Ser-Ile-Gly-Ser-Ser-X- Ile-OH and (b) H-Tyr-Leu-Asp-Gly-Ile-Ala-Ser-Ser-X-Ile-OH (the amino acid residues are notated by the three-letter notation defined by the IUPAC and TUB; X denotes Phe or Leu) is a neuropeptide, capable of modifying the strong contraction by the electrical stimulation of the anterior byssus retractor muscle of Mytilus edulis Linneaus and obtained from the ganglion of Helix pomatia produced in Hungary by combining high-performance liquid chromatography; however, this neuropeptide can be synthesized by using a commercially available peptide synthesizer. This peptide is not only useful as the neuropeptide but also capable of providing a new approach to medicines and agricultural chemicals, etc.;COPYRIGHT: (C)1994,JPO&Japio