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QUINAZOLINE DERIVATIVE, ITS PRODUCTION AND MEDICINAL PREPARATION CONTAINING SAID COMPOUND AND USED FOR EFFECTING ANTITUMOR ACTION IN WARM-BLOODED ANIMAL
QUINAZOLINE DERIVATIVE, ITS PRODUCTION AND MEDICINAL PREPARATION CONTAINING SAID COMPOUND AND USED FOR EFFECTING ANTITUMOR ACTION IN WARM-BLOODED ANIMAL
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机译:包含所述化合物的喹唑啉衍生物,其生产和药物制备,用于在温血动物中实现反作用
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摘要
The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- CHEM wherein R1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy; R2 is hydrogen or (1-4C)alkyl; R3 includes hydrogen and (1-4C)alkyl; and Ar is optionally substituted phenylene or heterocyclene; or a pharmaceutically-acceptable salt or ester thereof.
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机译:本发明涉及具有抗肿瘤活性的喹唑啉衍生物或其药学上可接受的盐。生产过程;以及含有它们的药物组合物。本发明提供下式的喹唑啉:-CHEM>其中R 1为(1-4C)烷基;喹唑啉环可任选地带有一个或两个另外的选自卤素,(1-4C)烷基和(1-4C)烷氧基的取代基; R 2为氢或(1-4C)烷基; R 3包括氢和(1-4C)烷基; Ar是任选取代的亚苯基或杂环基;或其药学上可接受的盐或酯。
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