PRODUCTION OF OPTICALLY ACTIVE ALPHA-(P-CHLOROPHENYL) ETHYLAMINE AND OPTICALLY ACTIVE ALPHA-(P-CHLOROPHENYL) ETHYLAMINE-P-CHLOROMANDELIC ACID SALT

摘要

PURPOSE: To obtain an optically active α-(p-chlorophenyl)ethylamine in a simple process and high yield using an optically active p-chloromandelic acid as an optical resolving agent. ;CONSTITUTION: (±)-α-(p-Chlorophenyl)ethylamine (CPEA) is made to react with an optically active p-chloromandelic acid (CMA) in a solvent, preferably methanol to form (+)-CPEA.(-)-CMA and/or (-)-CPEA.(+)-CMA which is a diastereomeric salt. Then the diastereomeric salt is selectively deposited from the solvent to separate the diastereomeric salt and the separated diastereomeric salt is decomposed to recover the optically active CPEA. The diastereomeric salt is expressed by the formula and is a new compound.;COPYRIGHT: (C)1993,JPO&Japio