RACEMIC OR OPTICALLY ACTIVE ALPHA- (2,3,4-TRIMETHOXYPHENAETHYLAMINOMETHYL) -2-HYDROXYBENZYL ALCOHOL AND PHARMACEUTICALLY ACIDIC ACID SALTS THEREOF.

摘要

Racemic or optically active alpha -(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylalcohol [I] may be prepared by condensing 2,3,4-trimethoxyphenethylamine with 2-benzyloxyphenylglyoxal or its hydrate, reducing the resultant alpha (2,3,4-tri-methoxyphenethylimino)-2-benzyloxyacetophenone to give alpha (2,3,4-trimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol, if required, resolving the 2-benzyloxybenzylalcohol derivative into each of its optically active enantiomers, and subjecting the racemic modification or optically active enantiomer of said 2-benzyloxybenzylalcohol derivative to catalytic hydrogenation. The compound [I] and pharmaceutically acceptable acid addition salts thereof are useful as anti-diabetic agents. They may be also used in the treatment of thrombosis.