首页> 外国专利> Attenuation for Dandelion Breeding Dogs Composite Pharmaceutical Inhibitors Prophylaxis Protoporphyrin IX Increase Prophylaxis for Dog Locale Localization Protoporphyrin IX Acquisition

Attenuation for Dandelion Breeding Dogs Composite Pharmaceutical Inhibitors Prophylaxis Protoporphyrin IX Increase Prophylaxis for Dog Locale Localization Protoporphyrin IX Acquisition

机译:蒲公英繁殖犬的衰减复合药物抑制剂预防原卟啉IX增加对犬局部定位的预防原卟啉IX的获得

摘要

Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphrinogen oxidase inhibitor.
机译:公开了通过在光可活化的四吡咯存在下使所述细胞经受光照来杀死哺乳动物肿瘤细胞的方法和药物组合物,其中所述改进包括用抑制原卟啉原酶转化为原卟啉IX的化合物处理所述细胞。通过原卟啉原氧化酶在所述细胞中的表达,从而导致原卟啉IX在所述细胞中的积累。还公开了生产原卟啉IX的方法,其包括在原卟啉原氧化酶抑制剂存在下生长真核微藻。

著录项

  • 公开/公告号LV10303A

    专利类型

  • 公开/公告日1994-10-20

    原文格式PDF

  • 申请/专利权人 FMC CORPORATION;

    申请/专利号LV19930001060

  • 申请日1993-09-09

  • 分类号C12N9/99;5C12R1:89B;C12P1/00;A61K37/02;

  • 国家 LV

  • 入库时间 2022-08-22 04:45:28

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