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Pharmaceutical composition containing a specific inhibitor of the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase
Pharmaceutical composition containing a specific inhibitor of the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase
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机译:药物组合物,其包含通过原卟啉原氧化酶将原卟啉原转化为原卟啉IX的特异性抑制剂
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摘要
A method and a pharmaceutical composition for killing mammalian tumour cells is disclosed and entails cells being exposed to light in the presence of a photoactivatable tetrapyrrole, the improvement consisting in the fact that these cells are treated with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in these cells, which brings about an accumulation of protoporphyrin IX in these cells. A process for the preparation of protoporphyrin IX is also disclosed and comprises the cultivation of eukaryotic microalgae in the presence of a protoporphyringen oxidase inhibitor.
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