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A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method.
A method of preparing a drug having an anti-tumor effect and a method of preparing steroid derivatives suitable for use in the former method.
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机译:具有抗肿瘤作用的药物的制备方法和适用于前一种方法的类固醇衍生物的制备方法。
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摘要
A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula IMAGE wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C1-C4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of -O-, -COO-, -CONH-, -NH- or IMAGE
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机译:产生选择性影响肿瘤或癌细胞的类固醇激素-抗肿瘤衍生物的方法包括使具有化学式的类固醇激素衍生物的X基团反应,其中ST代表具有having,雌激素或雄烷烃的环菲烃骨架的类固醇部分。通过将D环上的OH基与羧基酯化而与羧基结合; R 1表示C 1 -C 4亚烷基,X表示卤原子,氨基,羟基,羧基或其盐,其与抗肿瘤药的经修饰或未经修饰的反应性基团形成-的结合基团。 O-,-COO-,-CONH-,-NH-或<图像>
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