USE OF THERAPEUTIC CELLS TO OBTAIN CELLULAR RESPONSE TO INFECTION, TUMOURS OR AUTOIMMUNE-GENERATED CELLS, CELLS WITH CHIMAERIC RECEPTORS (WITH BINDING COMPONENT AND DESTRUCTION SIGNAL), DNA ENCODING THE RECEPTOR, VECTORS AND ANTIBODIES TO RECEPTOR

摘要

Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.