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METHOD OF OBTAINING NOVEL DERIVATIVES OF 24,24-DIHOMO-1,25 DIHYDROXYCHOLECALCIFEROL
METHOD OF OBTAINING NOVEL DERIVATIVES OF 24,24-DIHOMO-1,25 DIHYDROXYCHOLECALCIFEROL
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机译:获得新的24,24-DIHOMO-1,25二氢胆甾醇的衍生物
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摘要
Process of obtaining new 24,24-dihomo-1,25-dihydroxycholecalciferol derivatives with formula 1, where R denotes trialkylsilyl, characterised in that (5Z,7E)-(1S,3R)-1.3-bis-[t-butyldimethylsilyl]oxy]-9,10- seco-5,7,10(19)-cholatrien-24-oic is converted into p-toluenesulfonate with formula 2, with R retaining the above meaning, which is subsequently subjected to alkylation process using 2-methyl-4-(phenylsulfonyl)-2-[(trialkylsilyl)oxy] butane with formula 3 and the obtained product is separated using known methods.IMAGE
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