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A method for preparing populations lipid, liposomes vesicles of uniform size.

机译:一种制备种群大小均匀的脂质,脂质体囊泡的方法。

摘要

The present invention provides novel methods for generating vesicles (liposomes) lipid multilamellar encapsulating aqueous liquid in which one or more lipids, or conjugated lipids, and an aqueous liquid to be encapsulated are stirred into a glass IN THE PRESENCE OF MASSES CONTACT ESFERICO MIDDLE having a diameter of less than 3,000 microns, the size range 50-100 IS FAVORITE IN mICRON dIAMETER AND RESULTING IN A substantially homogeneous population of vesicles having diameters in the range of about 150 to 3,000 nanometers. The method allows FOR USE OF SMALL QUANTITIES OF MARKER AND LIPID, DEJA SOLVENTS nonresidual, CRISTALINAS, AND ACTIVE PREPARATIONS NOT TRANSFER OF VESSEL LIPOSONAS DRYING OF FILMS FOR lipid grading equipment.
机译:本发明提供了用于产生囊泡(脂质体)脂质多层囊封的水性液体的新方法,其中将一种或多种脂质或缀合的脂质以及待囊封的水性液体搅拌到玻璃中。直径小于3,000微米,尺寸范围为50-100在米卡直径中是最喜欢的,并且导致直径在约150至3,000纳米范围内的基本上均匀的囊泡群。该方法允许使用小数量的标记物和脂质,非残留的DEJA溶剂,克里斯汀菌属,以及用于脂质定级设备的不干燥容器脂蛋白干燥的活性制剂。

著录项

  • 公开/公告号ES2056874T3

    专利类型

  • 公开/公告日1994-10-16

    原文格式PDF

  • 申请/专利权人 ABBOTT LABORATORIES;

    申请/专利号ES19880118298T

  • 发明设计人 WONG MARTIN;

    申请日1988-11-03

  • 分类号A61K9/50;G01N33/543;

  • 国家 ES

  • 入库时间 2022-08-22 04:42:49

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