PHOSPHOINOSITIDE-BINDING PEPTIDES DERIVED FROM THE SEQUENCES OF GELSOLIN AND VILLIN

摘要

The present invention is based on the identification of two peptide fragments of gelsolin which are capable of inhibiting PPI/gelsolin and PPI/enzyme interaction by binding to PPI. Based on these observation agents are described which are capable of modulating PPI/gelsolin and PPI/enzyme interaction by binding to the PPI binding site of gelsolin and gelsolin binding site of PPI. The present invention further discloses method of identifying agents capable of modulating PPI/gelsolin interaction.