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NON-SHEDDING LIVE HERPESVIRUS VACCINE

机译:非播种活疱疹病毒疫苗

摘要

The present invention is concerned with a genetically modified live herpesvirus vaccine of which the live herpesviruses are not shed into the environment by a vaccinated animal. This can be achieved by deleting an essential gene of the herpesvirus and propagating this deletion mutant in a cell line expressing the gene product of the essential gene. The reduced shedding characteristic of such a vaccine is in particular advantageous in a vector vaccine.
机译:本发明涉及转基因活疱疹病毒疫苗,其中该活疱疹病毒不会被接种动物释放到环境中。这可以通过删除疱疹病毒的必需基因并在表达该必需基因的基因产物的细胞系中繁殖该缺失突变体来实现。这种疫苗的减少的脱落特性在载体疫苗中特别有利。

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