Viper venom polypeptides and genetic expression

摘要

A platelet aggregation inhibiting polypeptide having the following amino acid sequence: X-Cys-R-R-R-Arg-Gly-Asp-R-R-R-R-R-Cys-Y where X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid. Genetically engineered genes for the polypeptides are described and expressed as a fusion protein using the pJC264 expression vector in E. coli. Synthetic polypeptides and methods of synthesis are also described.