Beta-carboline derivatives with anticholecystoquinine activity

摘要

Disclosed are a β-carboline derivative represented by the formula:    wherein R¹ represents hydrogen atom, a lower alkyl group, a lower alkoxy group or hydroxy group; R⁵ represents hydrogen atom, or R¹ and R⁵ are bonded to represent a lower alkylenedioxy group; R² represents hydrogen atom, a halogen atom, a lower alkoxy group or hydroxy group; R³ represents hydrogen atom, a carbamoyl lower alkyl group, a lower alkyl group, a carboxy lower alkyl group or a lower alkoxycarbonyl lower alkyl group; R⁴ represents hydrogen atom, a lower alkyl group, a carboxy lower alkyl group, a lower alkoxycarbonyl lower alkyl group, a lower alkanoyl group, an arylcarbonyl group, a lower alkanesulfonyl group, a lower alkoxycarbonyl group, an aralkyl group, formyl group or a di(lower alkyl)sulfamoyl group; n represents 0, 1 or 2; and the symbol * represents an asymmetric carbon atom,or a pharmaceutically acceptable salt thereof,and a process for preparing the same.