Development of a mechanism-based screen to identify androgen receptor agonists and antagonists

摘要

The present invention relates to a novel androgen receptor screening method using a yeast-based expression system. The use of this yeast system enhances the ability to screen for agonists and/or antagonists of the steroid thyroid receptor superfamily. Furthermore, the use of this yeast system allows the localization and identification of functional domains of the androgen receptor.