N-methansulfonyl-2-(3-isobutyl-3-(quinol-2-yl-methoxy)-phenyl)-2-cycloalkylacetamides, process for their preparation and their pharmaceutical use

摘要

Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula IMAGE in which R1 stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R1 stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.