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METHOD OF SYNTHESIS OF N-HYDROXYREAS DERIVATIVES AS R- OR S-ENANTIOMETRIC FORMS OR THEIRS MIXTURE, OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS WITH ALKALINE METAL
METHOD OF SYNTHESIS OF N-HYDROXYREAS DERIVATIVES AS R- OR S-ENANTIOMETRIC FORMS OR THEIRS MIXTURE, OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS WITH ALKALINE METAL
The use in medicine, since the products have pharmacological aktivnost.o The inventive method for producing the novel N-derivatives mochevinobscheyformuly Ar-OAr1-Y-CH (CH bN (OH) (CONHR1) where Ar - 3, 4-halophenyl; Ar -. 1.3 or 1,4-phenylene, Y - / E / - CH CH, R - C -C alkyl vodoro as R- or S-enantiomeric form, or mixtures thereof, or their pharmaceutically acceptable salts with schelochnymmetanolomReagentV Ar-QAr - Y-CHfCH NHOH, wherein Ar, Ar1, Y are as defined above Reagent 2 tsinat alkali metal reaction conditions in a solvent at O & amp; deg; C, in the presence of HCI Ztabl.
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机译：由于产品具有药理学活性，因此可在药物中使用。本发明的方法用于生产新型N衍生物，分子式为Ar-OAr1-Y-CH（CH bN（OH）（CONHR1），其中Ar-3，4-卤代苯基; Ar -。1.3或1,4-亚苯基，Y-/ E /-CH CH，R-C -C烷基vodoro（R-或S-对映体形式），或它们的混合物，或它们与schelochnymmetanolomReagentV Ar-QAr- Y-CHfCH NHOH，其中Ar，Ar1，Y如上所定义。在HCl Ztabl存在下，在O＆amp; C的溶剂中，试剂2碱在碱金属反应条件下进行。
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