A device for measuring the ph of a target, and advantages of using said device and its applications.

摘要

Device for measuring the pH of an appropriate target, particularly a tumor, without direct contact with said target, method for using such device as well as its applications, particularly to the control of treatment of tumors by hyperthermy. The pH measuring device is comprised of: an excitation source (10) which includes a light source (101) appropriate for selecting at least two waves lengthes for excitation of the fluorescence of a fluorescent marker fixed to said target and whose fluorescence emission spectrum depends on the pH, which source is associated with a spherical mirror (102), a condenser (103), a lens (104), filters (105), to trigger means (106) for switching from one excitation wave length to the other and to a lens (20) which focuses the light to a transmission means (30) from said light source to the target (40); at least one collector means (50) for collecting the emitted fluorescence; one sensor and reading means (60, 70, 80) for detecting and reading the emitted fluorescence; and a system for calculating the pH of the target from the ratio of emitted fluorescence signals obtained successively at least at both excitation wave lengthes (90).