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Method of manufacturing fibrinogen of very high — purity, fibrinogen of very high — purity obtained as well as a pharmaceutical composition containing.
Method of manufacturing fibrinogen of very high — purity, fibrinogen of very high — purity obtained as well as a pharmaceutical composition containing.
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机译:制备非常高纯度的纤维蛋白原的方法,获得的非常高纯度的纤维蛋白原以及包含其的药物组合物。
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摘要
The invention relates to a process for the production of high-purity fibrinogen. This process is characterized in that it comprises, from blood plasma cryoprecipitate of animal or human origin, an aqueous solution, the treatment of this solution in order to bring it to an ionic force equal to that of a buffer solution which has the following composition: & br / (see appended drawing in bopi) & br / & & br / is passed through this solution of ionic force adjusted on an anion exchange column comprising a gel of the anion exchange, for example in the form of balls, based on agarose crosslinked comprising quaternary amine groups, in particular at the end of a spacer arm, for example alkylene type c1 - c6 connected to the agarose beads, in particular to approximately 6% agarose and then an elution with a first solution of elution of the same ionic strength, these conditions, making it possible to selectively adsorb the fibrinogen on said column, which is desorbed by elution solution of ionic strength higher at approximately 200 mm nacl. & br / it is possible to obtain a high-purity fibrinogen.
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