Improved processes for producing a polyether antibiotic compound represented by A82810 comprising: (1) cultivating Actinomadura fibrosa sp. nov. NRRL 18348 or Actinomadura sp. NRRL 18880, (2) feeding acid hydrolyzed casein at a rate from about 2.50-7.50 gm/L/day, (3) feeding glucose at a rate from about 2.50-7.50 gm/L/day, and (4) feeding propionate at a rate from about 0.50-1.5 gm/L/day to the appropriate culture medium during fermentation, are provided.
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机译：制备由A82810代表的聚醚抗生素化合物的改进方法，包括：（1）培养纤维放线猕猴桃。十一月NRRL 18348或Actinomadura sp。 NRRL 18880，（2）以约2.50-7.50 gm / L /天的速度添加酸水解酪蛋白，（3）以约2.50-7.50 gm / L /天的速度添加葡萄糖，和（4）在发酵过程中，向合适的培养基提供约0.50-1.5 gm / L /天的速率。
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