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Method for temporarily inhibiting or deactivating serine hydrolase and adduct of serine hydrolase with a phosphonate or phosphate compound
Method for temporarily inhibiting or deactivating serine hydrolase and adduct of serine hydrolase with a phosphonate or phosphate compound
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机译:暂时抑制或失活丝氨酸水解酶和丝氨酸水解酶与膦酸酯或磷酸酯化合物加成的方法
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摘要
Phenacyl phosphonate adducts of serine hydrolases temporarily inhibit or inactivate the serine hydrolases. The serine hydrolases are activated by intramolecularly catalyzed dephosphonylation of the adduct over a period of time. Half-lives for dephosphonylation in the range of about 30 to 500 minutes have been observed at physiological pH's.
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