Effective thrombosis mediated by human prourokinase-like polypeptides with increased binding affinity for thrombosis

摘要

Human prourokinase-like polypeptides of which oligopeptides having a structure to form a covalent bond with blood clot (thrombus) through enzymatic action of human blood coagulation factor XIII are attached to the NH.sub.2 -terminal sides of human prourokinase derivatives.