首页>
外国专利>
The sustained-release medicine formulation null which possesses pH control film
The sustained-release medicine formulation null which possesses pH control film
展开▼
机译:具有pH控制膜的缓释药物制剂无效
展开▼
页面导航
摘要
著录项
相似文献
摘要
A sustained-release pharmaceutical preparation utilizing a pH controlled diffusion membrane composed of a pH sensitive film-forming polymer. The film forming polymer may be an enteric polymer containing phthalic acid with one carboxyl group attached to the enteric polymer via an ester bond, and the second carboxyl group remaining a free acid so that the modified film forming polymer is hydrophobic at low pH and hydrophilic at higher pH. Hydrophobic stearyl side chains are attached to the enteric polymer which causes the pH controlled diffusion membrane to remain insoluble at high pH. Alternatively, the pH sensitive film forming polymer may be a polymer containing hydrophobic and free acid groups so that the modified film forming polymer is hydrophobic at low pH and hydrophilic but insoluble at high pH. In the preferred sustained-release pharmaceutical preparation the film forming polymer is coated onto core drug particles to produce a pH controlled diffusion membrane surrounding the core drug and form microparticles which may be admixed with free drug or time-release drug and placed in a gelatin capsule or tabletted.
展开▼