PRODUCTION OF SURFACE ANTIGEN PROTEIN OF JAPANESE ENCEPHALITIS VIRUS USING MAMMALIAN CELL

摘要

PURPOSE:To provide a new production process of surface antigen protein of Japanese encephalitis virus which is useful as a prophylactic medicine or diagnostic agent for Japanese encephalitis. CONSTITUTION:An expression vector into which the whole or a part of cDNA coding for the surface antigen protein (E protein) of Japanese encephalitis virus is incorporated together with the whole or a part of cDNA coding for the matrix protein of the virus, or the whole or a part of cDNA coding for the prematrix protein of the virus, or a part of the core protein of the virus, is introduced into the host mammalian cells to effect efficient production of E (envelope) protein.