Cloning and expression of Escherichia coli polypeptide for malaria vaccine

摘要

A vaccine for protecting mammals against malaria is prepared by a process comprising inserting a coding sequence for all or a portion of the repeat unit of the CS protein of Plasmodium falciparum into an E. coli expression vector such that the coding sequence is operatively linked to a regulatory element, culturing the transformed E. coli such that the polypeptide is produced and purifying the polypeptide therefrom.