PROCESS OF STEREOSELECTIVE PREPARATION OF BETA-PHENYLISOSERIN DERIVATIVE AND ITS USE FOR PREPARATION OF TAXAN DERIVATIVES

摘要

the preparation method stereoselektivnu00ed derivative beta - phenyl - isoserrinu formula consists in the reaction of n - karbonylbenzyl - iminu formula ii with optically active amidem protected acid hydroxyoctovu00e9 formula iii and nu00e1sledno hydrolysis of the product thus obtained. in the formulas i, ii and iii, r is a phenyl group which may substituovu00e1na or r.sub.1.n.- o, ar is arylovou group, which is possibly substituovu00e1na, and g.sub.1.n. means the group of hydroxy functions.the product is particularly applicable to the preparation of formula i taxolu and taxoteru which have remarkable anticancer properties. and