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4-amidino-chroman and 4-amidino-pyrano (3,2-c) pyridine derivatives, process for their preparation and to pharmaceutical compositions containing them
4-amidino-chroman and 4-amidino-pyrano (3,2-c) pyridine derivatives, process for their preparation and to pharmaceutical compositions containing them
4-Amidinochroman and 4-amidinopyrano[3,2-c]pyridine derivatives, process for obtaining them and pharmaceutical compositions containing them. The said derivatives have antihypertensive and antiarrhythmic activities. They correspond to the formula: …IMAGE… in which: … … . A + B = -CH=CH-CH=N- or -CH=CR4-CR5=CH-; … . X = N, N-O, C-Z; … . R1 = H, CN, NO2, C1-C4 alkyl, OH, C1-C4 alkoxy, CF3CO-, CH3-SO2-, phi -SO2-; … . R2 = H; … . R3 = OH or OCOCH3 or R2 + R3 = double bond. …
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机译：4-A基苯并二氢吡喃和4-op基吡喃并[3,2-c]吡啶衍生物，获得它们的方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗心律不齐的活性。它们对应于以下公式：……其中：……。 A + B = -CH = CH-CH = N-或-CH = CR4-CR5 = CH-; ……。 X = N，N-> O，C-Z; ……。 R1 = H，CN，NO2，C1-C4烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-，phi -SO2-; ……。 R2 = H; ……。 R 3 = OH或OCOCH 3或R 2 + R 3 =双键。 …
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