DERIVATIVES OF 1,2,3,4-TETRAHYDRO-BENZOFURO 3,2-C PYRIDINE, USE OF THEM AS WELL AS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

PCT No. PCT/EP98/02136 Sec. 371 Date Oct. 4, 1999 Sec. 102(e) Date Oct. 4, 1999 PCT Filed Apr. 2, 1998 PCT Pub. No. WO98/45297 PCT Pub. Date Oct. 15, 1998The present invention concerns the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; Alk is C1-6alkanediyl; n is 1 or 2; D is an optionally substituted mono-, bi- or tricyclic nitrogen containing heterocycle having central alpha 2-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine.