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LIPOSOMES WITH AT LEAST TWO SEPARATE CHAMBERS ENCAPSULATING TWO SEPARATE BIOLOGICALLY ACTIVE SUBSTANCES
LIPOSOMES WITH AT LEAST TWO SEPARATE CHAMBERS ENCAPSULATING TWO SEPARATE BIOLOGICALLY ACTIVE SUBSTANCES
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机译:脂质体,具有至少两个单独的小室,包含两个单独的生物活性物质
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摘要
Disclosed are heterovesicular liposomes containing different biological compositions (14, 14a) each encapsulated in separate chambers of the liposomes, having defined size distribution, adjustable internal chamber size and number, methods of making them and treatment of patients with them. The preparation process includes the addition of composition to first lipid component in the vial to obtain an emulsion, the addition of composition to second lipid component in the vial to obtain a second emulsion and mixing these emulsions to form a chimeric emulsion.
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