PROCESS FOR SCREENING SUBSTANCES HAVING A MODULATING EFFECT ON ANY INTERLEUKIN-5 RECEPTOR MEDIATED CELLULAR SIGNAL TRANSMISSION PATHWAY

摘要

A process is disclosed for screening substances having a modulating effect on the interleukine-5-receptor-dependent signal transmission path in mammal cells. Test substances are applied on cells which express the functional interleukine-5-receptor and are transformed with a recombinant DNA containing a reporter gene and a regulatory sequence functionally linked thereto which is sensitive to a change in concentration of a secondary messenger substance of the interleukine-5-receptor-dependent signal transmission path. Substances specific to the interleukine-5-receptor-dependent signal transmission path and with potential pharmacological effect may be identified by this process.