Mck-10 (mammary carcinoma kinase 10), a receptor tyrosine kinase
展开▼
机译:Mck-10(乳癌激酶10),受体酪氨酸激酶
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK-10 and to other members of the MCK-10 receptor tyrosine kinase family. Genetically engineered host cells that express MCK-10 may be used to evaluate and screen drugs involved in MCK-10 activation and regulation. The invention relates to the use of such drugs, in the treatment of disorders, including cancer, by modulating the activity of MCK-10.
展开▼