NEW CENTRALLY ACTING 5-, 6-, 7-, AND 8-SUBSTITUTED SULPHONE ESTERS OF N-MONOSUBSTITUTED 2-AMINOTETRALINS AND RELATED STRUCTURES

摘要

A compound of formula (1) or pharmaceutically acceptable acid addition salts thereof, wherein R1 is H, (C1-C8) alkyl, alkenyl, alkynyl, cyclopropylalkyl or (C1-C8) haloalkyl; X is CH2, O or S; R2-SO2-O is in position 5, 6, 7 or 8 and R2 is CF3, CF2CF3, C1-C8 alkyl, substituted aryl (e.g. 4-toluyl); R3 is H, CH3 or CH2CH3. When R3 is CH3 or CH2CH3, it is always in a cis-relationship with respect to the 2-amine substituent.