INDOLINE DERIVATIVE AND 5-HT3 RECEPTOR ANTAGONIST CONTAINING THE SAME AS ACTIVE INGREDIENT

摘要

An indoline derivative represented by general formula (I); a physiologically acceptable salt thereof; solvates of these compounds; and a 5-HT3 receptor antagonist containing the same as the active ingredient. In said formula, R1 represents the group (a) ou (b); R2 represents optionally substituted phenyl or heteroaryl; and R3 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, carbamoyl or lower alkoxycarbonyl. The derivative has a potent antagonism against 5-HT¿3? receptors in the intestinal tract as compared with the known 5-HT3 receptor antagonists and is excellent in the persistence of the activity. Hence it is useful for preventing or treating vomiting or nausea induced by chemotherapy or radiation, irritable bowel syndrom and diarrhea.